???10??31????????????????Halloween????С??????????????????????????????????????????????????trick or treat (??????????) ???????????????Google Deepmind????????????????????Deepmind???????????? Isomorphic Labs ??????????????AlphaFold????AlphaFold3??1??????????????????о??巽?????????????????????????????????????????????????????????trick????treat?? 

???????????????????壬?????20???????????????????????????????????/???????????????????????????????б??????????????????????????????????????Σ????????????棨work in progress??????????????????AlphaFold3????????AlphaFold2????????????????????????????????????????????????????????С???????塢?????????????????????DNA ??RNA????????з???????Σ?PTM?????????????????????????????

??????????????????????????????????????????????RNA??????????????д?2020??AlphaFold2????????????????????????????????????????????????????SOTA?????????????????????-??????????????????????????30%????????????????????-????????????????17%?????????-??????????????50%?????????RMSD<2Å?????????CASP15??RNA?????AlphaFold3???????????????,????????BRiQ??????????AIchemy_RNA2??????2??3????

??????????·??????????????????????????????ж?AlphaFold3???????????Σ??????????????м????????????????????????????????????????????????????????????????????????????????????????????trick????treat????????????????????????Σ?AlphaFold3?????????????????RNA?????????????????????????AIchemy_RNA2?????ж????RNA??????????????RMSD<2Å????

???????????????????

??1??A glimpse of the next generation of ALphaFold. https://www.isomorphiclabs.com/articles/a-glimpse-of-the-next-generation-of-alphafold

??2??K. Chen, Y. Zhou, S. Wang, and P. Xiong. RNA tertiary structure modeling with briq potential in casp15. Proteins: Structure, Function, and Bioinformatics, 2022. doi: 10.1002/prot.26574. 

??3??P. Xiong, R. Wu, J. Zhan, and Y. Zhou. Pairing a high-resolution statistical potential with a nucleobase- centric sampling algorithm for improving RNA model refinement. Nature Communications, 12(1): 2777, May 2021. ISSN 2041-1723. doi: 10.1038/s41467-021-23100-4. 

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