·??????????????? /u/zhpd55 ??????????????????????????С???

????

?о???????????????? ???

???? 4103 ????? 2021-9-17 14:41 |???????:????|??????:???????

?о????????????????

???

1-s2.0-S2589004221009809-fx1_lrg.jpg

Grahpical abstract. Credit: DOI: 10.1016/j.isci.2021.103012

??????????????????University of East Anglia???UEA??2021??9??16????????????????????????????????????????????о???????????????????????Research breakthrough could protect against breast cancer progression?????????????????????????????ú?С????????????????????????????????????????????????????????????????????о??????2021??9??16????????iScience????????????????Alastair M. McKee, Benjamin M. Kirkup, Matthew MadgwickWesley J. Fowler, Christopher A. Price, Sally A. Dreger, Rebecca Ansorge, Kate A. Makin, Shabhonam Caim, Gwenaelle Le Gall, Jack Paveley, Charlotte Leclaire, Matthew Dalby, Cristina Alcon-Giner, Anna Andrusaite, Tzu-Yu Feng, Martina Di Modica, Tiziana Triulzi, Elda Tagliabue, Simon W. F. Milling, Katherine N. Weilbaecher, Melanie R. Rutkowski, Tam??s Korcsm??ros, Lindsay J. Hall1, Stephen D. Robinson. Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth. iScience, 2021, Volume 24, Issue 9, 24 September 2021, 103012. DOI: 10.1016/j.isci.2021.103012. http://dx.doi.org/10.1016/j.isci.2021.103012

????????????????о????????????????????????Breast Cancer Now?????????????о??У????????UEA??Quadram???????о?????Quadram Institute Bioscience?????????????о?????Earlham Institute??????????????????University of Glasgow????????????????????University of Virginia?????????·????????????Washington University in St Louis?????????????????о????????Fondazione IRCCS Instituto Nazionale di Tumori, Milan?????????????????????Technical University of Munich???????о??????????????ù?????????broad-spectrum antibiotics??????С??????????????????С???????????????????????????????????????????????????????????????????С????????

??Quadram?о????鳤??UEA?о??鳤??????????????Dr. Stephen Robinson?????????????о?С??????????????????β?????????????????(cefalexin)???????о?????????????????????????С????????????????о????????????????????????????????????????????????????????????????????

???????????о????о?С?黹???????????????????С????????????У????????????(mast cells)?????????????????????Щ?????????????????????????????????????????????????(aggressive growth)???????????Щ????????????????????????????????????????????????????Щ???????????????????????????

??????????????????????????????????????????????????е????????????????????????????????????????????????????????????????????????κθ????

Quadram?о??????鳤??UEA??????????UEA's School of Biological Sciences?????о????????????????????:????????????????????????????????????????????????????????????????С????????о????????????????????????????????????????з????????????????????????????????????з???????????á???????о??????????????????????????С????桯?????????????????????????????????????????????????????????????????????????漰?????????????????????????е????????б???????????δ?????о??????????????Щ?????????????????????????????????????????????????

??????????????????????????????????5.5????????370???????????????????????(???????)??????????????????????????鷿???????????????????????????????????λ??

???в?????ж???????м????????????????????????3.5??????????????????????????????????????????????????е???????????

???????????iScience???????????о??У???????????????????????????????????????????Alastair McKee??????????????????δ??????????????С????????????????С???鷿?????????????????Ч???????????????????????С??????ж???????о?С???????о????????????????仯?????????????????????С???????????е???????????????

?о??????????????cromolyn??????????????????????????????????????Щ?????????????????????????????С???н??????????????????????????????С?????????????????????????????????????????????й??????

?о?????????????????飬???????????????????ζ???????????????????????????·???????????δ??????????????????????????????????????????????????????????????????????????????????????????????????????????????Щ??????????????????????С??

???????????????????о?????????????Σ?Director of Research, Support and Influencing at Breast Cancer Now?????ɡ??????????Dr. Simon Vincent???:??????????10????????????????????????????????????????????????????????????????????????????????????????????????????????????о????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????о???????????????????????????????????????????????????????????????????????????????о??????????????????????????????о???????????????????е?????????????????????????????????????????????????????????о????????????????????????????п????????????????????????????

??????????????о??е?????????????COVID-19??????????????????????缶?о?????????????????????????????????????о????????????????????????????????????????????????????о??δ???????????????????κ??????????????

??????????????ο?????????????????????????????????????????

Targeting essential protein could lead to new breast cancer treatments

Highlights

• Microbiota disturbances promote tumor growth in several breast cancer models

• Increased tumor volume positively correlates with stromal mast cell density

• Supplementation with a commensal restores tumor growth to normal

Summary

The gut microbiota??s function in regulating health has seen it linked to disease progression in several cancers. However, there is limited research detailing its influence in breast cancer (BrCa). This study found that antibiotic-induced perturbation of the gut microbiota significantly increases tumor progression in multiple BrCa mouse models. Metagenomics highlights the common loss of several bacterial species following antibiotic administration. One such bacteria, Faecalibaculum rodentium, rescued this increased tumor growth. Single-cell transcriptomics identified an increased number of cells with a stromal signature in tumors, and subsequent histology revealed an increased abundance of mast cells in the tumor stromal regions. We show that administration of a mast cell stabilizer, cromolyn, rescues increased tumor growth in antibiotic treated animals but has no influence on tumors from control cohorts. These findings highlight that BrCa-microbiota interactions are different from other cancers studied to date and suggest new research avenues for therapy development.



/blog-212210-1304596.html

????????????????á???????桱???COVID-19
??????UCLA?о????????????????????????????Ч
???

4 ???? ????? ?????? ??????

?ò????????????????? ??????? ???? (2 ??????)

?????????...

Archiver|?????|????? ( ??ICP??07017567??-12 )

GMT+8, 2021-10-16 19:44

Powered by ScienceNet.cn

Copyright © 2007- ?й????????

???????